| Time-day 1(min) | Time-day 28 (min) | Time-day 56 (min) | Time-day 84 (min) | |
| Botox Group | 245 ± 69 | 59 ± 28 | 57 ± 13 | 70 ± 22 |
| 25-Pro Group | 246 ± 95 | 57 ± 32 | 84 ± 16 | 176 ± 56 |
| 33-Pro Group | 252 ± 69 | 59 ± 28 | 65 ± 13 | 68 ± 34 |
| ControlGroup | 246 ± 80 | 65 ± 42 | 228 ± 74 | 240 ± 77 |